KM plots using data from a Local Xena Hub
To visualize and perform a KM analysis, we use two columns/rows of data, time to event and event. These data must be loaded in a phenotype file. The phenotype file can contain other data as well.
Note that you will need to name the headers in your phenotype file EXACTLY what we recognize. See the list of recognized headers for each type of survival/interval below.
This data can be in days, months, years, etc.
Time to Event and Event
Time to Event is a duration variable for each subject having a beginning and an end anywhere along the timeline of the complete study. It begins when the subject is enrolled into a study or when treatment begins, and ends when the end-point (event of interest, for example, death or metastasis) is reached or the subject is censored from the study.
Censoring means the total survival time for that subject cannot be accurately determined. This can happen when something negative for the study occurs, such as the subject drops out, is lost to follow-up, or the required data is not available or, conversely, something good happens, such as the study ends before the subject had the event of interest occur, i.e., they survived at least until the end of the study, but there is no knowledge of what happened thereafter.
Event indicates what the 'event' was for a patient, 1 for the event, for example, death or metastasis, and 0 for censored.
Recognized header names for different types of survival
Below is a table of the column/row header names we recognize for each type. Note that these header names are case sensitive.
Survival Type
'Time to Event' Header name
'Event' Header name
Overall Survival
OS.time
OS
Disease free interval
DFI.time
DFI
Disease specific survival
DSS.time
DSS
Progression free interval
PFI.time
PFI
Local recurrence interval
LRI.time
LRI
Distant metastasis interval
DMI.time
DMI
Distant disease free survival
DDFS.time
DDFS
Invasive disease free survival
IDFS.time
IDFS
Regional recurrence
RR.time
RR
Relapse
Relapse.time
Relapse
Metastasis
Metastasis.time
Metastasis
Distant recurrence interval
DRI.time
DRI
Distant metastasis free survival
DMFS.time
DMFS
Example Overall Survival
sample
OS
OS.time
TCGA-AB-1234-01
0
100
TCGA-AB-6789-01
1
200
TCGA-CD-1234-01
0
300
TCGA-CD-5678-01
1
400
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